What is ELIGARD® (leuprorelin acetate)?
ELIGARD® is indicated for the palliative treatment of advanced prostate cancer.1 ELIGARD® is a sterile polymeric matrix formulation of leuprorelin acetate for subcutaneous injection. It is designed to deliver leuprorelin acetate at a controlled rate over a therapeutic period.1
THE POWER OF CHOICE1‡
‡ Choice of 1-month (7.5 mg), 3-month (22.5 mg) 4-month (30 mg) or 6-month (45 mg) injections.1
Only ELIGARD® offers a choice of 1, 3, 4 and 6-monthly dosages,1 giving you the flexibility to tailor treatment to suit the specific requirements of each of your patients.
Reliable and sustained testosterone
suppression at 4 doses1
Serum testosterone suppression is comparable to bilateral orchidectomy.1
In clinical trials, ELIGARD® suppressed serum testosterone to ≤50 ng/dL in:1
- 94.1% of patients receiving ELIGARD® 1-monthly by day 28, and in 100% by day 422
- 99% of patients receiving ELIGARD® 3-monthly by day 28, and in 100% by day 353
- 96% of patients receiving ELIGARD® 4-monthly by day 28, and in 100% by day 424
- 99% of patients receiving ELIGARD® 6-monthly by day 285
Serum testosterone levels following injection with ELIGARD® 1-5Adapted from the ELIGARD Product Information.1
ELIGARD®/Atrigel® delivery system
ELIGARD® (leuprorelin acetate), indicated for palliative treatment of advanced prostate cancer, incorporates the Atrigel® delivery system.1
After injection, the Atrigel®/leuprorelin acetate mixture forms a solid drug delivery depot, slowly releasing leuprorelin acetate over a controlled period of time.1
Biodegradable The Atrigel® implant is fully biodegradable and therefore does not require removal prior to the next injection.1
Ease of injection The Atrigel® liquid formulation allows for small injection volumes and uses standard needles and syringes for ease of administration.6
Biocompatible All components of the Atrigel® system are biocompatible and each has established safety and toxicity profiles.1
Convenience1 - Small delivery volumes, short needles
ELIGARD's short needle size and small delivery volume make it highly acceptable to patients.8
Comparison of LHRH agonists1,8-10
- ELIGARD® Product Information.
- Perez-Marreno R et al. Clin Ther 2002; 24: 1902-14.
- Chu FM et al. J Urol 2002; 168: 119-203.
- Sartor O et al. Urology 2003; 62: 319-23.
- Crawford ED et al. J Urol 2006; 175: 533-6.
- TOLMAR Australia Data on file May 2015.
- Patel DB. J Global Pharma Technology 2010; 2: 85-90.
- Berges R. Eur Urol Suppl 2005; 4: 20-5.
- Zoladex 3.6 mg and Zoladex 10.8mg Product Information.
- Lucrin and Lucrin Depot Product Information.
PBS Information: Authority Required (STREAMLINED) Locally advanced
(equivalent to stage C) or metastatic (equivalent to stage D) carcinoma of the prostate.
Please review full Product Information before prescribing.
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ELIGARD® Minimum Product Information: INDICATIONS: Palliative treatment of advanced prostate cancer. Treatment of high-risk localised and locally advanced hormone-dependent prostate cancer in combination with radiotherapy. DOSAGE: One subcutaneous injection of Eligard® every one/three/four/six months. Do not inject in the arm. CONTRAINDICATIONS: Hypersensitivity to GnRH, GnRH agonist analogues or any excipients; pregnancy (Category D) and lactation; paediatric patients; previous orchiectomy; sole treatment in patients with spinal cord compression or evidence of spinal metastases. PRECAUTIONS: Transient increase in serum testosterone causing bone pain, neuropathy, haematuria, urinary tract obstruction; spinal cord compression and/or ureteral obstruction; hypogonadism; metastatic vertebral lesions; hyperglycemia and diabetes; cardiovascular risk factors, QT interval prolongation; changes in bone density; convulsions. INTERACTIONS: Medicinal products known to prolong QT interval or Torsade de Pointes such as Class IA, III antiarrythmics, methadone, moxifloxacin, antipsychotics. ADVERSE EFFECTS: Flare phenomenon; injection site reaction; malaise, fatigue; dizziness; weakness; lethargy; syncope; rigors; alopecia; pruritis; myalgia; arthralgia; limb pain; atrophy, or pain of testes; decreased libido; gynaecomastia; reduced penile size; musculoskeletal disorders; nervous system disturbances; insomnia; depression; hot flashes/sweats; haematologic disorders; urinary disorders; gastrointestinal disorders; nausea; weight increase; cardiovascular disorders. See full PI for full list of adverse effects. Based on PI Oct 2017.